Size : 1
P1(RMB) : 469
MW : 2278.7
One letter sequence : ARRKWQKTGHAVRAIGRLSS
Molecular Formula :
Description : This is amino acids 796 to 815 fragment of the chicken gizzard smooth-muscle myosin light-chain kinase (smMLCKp or P7) peptide, calmodulin (CaM)-binding domain . It retains its affinity for CaM and represents an adequate model for a complex of CaM with intact smMLCK protein. In the globular (Ca2+)4-CaM-P7 complex, the protein is wrapped around the -helical peptide. All the lysine and arginine charges of P7 are in close contact with the negatively charged side chains of the acidic residues of CaM. Calmodulin operates as a Ca2+ sensor and is known to interact with and regulate hundreds of proteins involved in many aspects of cellular function.
Literature Reference : Frederick, K. et al. Nature 448, 325 (2007); André. I. et al. Biophys. J. 90, 2903 (2006)