Chinese Peptide Company


[Lys(Ac)373]-p53 (368-393), p53 K373(Ac), biotin-labeled, human
Size : 1
P1(RMB) : 1490
MW : 3610.2
One letter sequence : Biotin-KGWHLKSK-K(Ac)-GQSTSRHKKLMFKTEGPDSD-NH2
Molecular Formula :
Description : This is a biotin-labeled and amidated peptide derived from residues 368-393 of human p53 tumor suppressor protein with acetylation at Lys373 and additional KGW residues on its N-terminus. Activated p53 functions to induce cell cycle arrest and apoptosis in response to signals such as DNA damage. Acetylation of p53 reduces ubiquitination by MDM2 and increases p53 half-life in vivo.
Literature Reference : Kubbutat, M. et al. Lett Nature 387, 299 (1997) Li, M. et al. J Biol Chem 277, 50607 (2002).
Cas :