Chinese Peptide Company


(Ala1)-PAR-4 (1-6) amide (mouse)
H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 Trifluoroacetate salt
Size : 5
P1(RMB) : 787
MW : 680.8
One letter sequence : AYPGKF-NH2
Molecular Formula : C34H48N8O7
Description : This peptide based on the proteolytically-revealed tethered ligand sequence of the murine proteinase-activated receptor-4 (PAR-4) was shown to cause platelet aggregation with an EC50 value of about 15 µM. PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.
Literature Reference : T.R.Faruqi et al., J. Biol. Chem., 275, 19728 (2000) M.D.Hollenberg and M.Saifeddine, Can. J. Physiol. Pharmacol., 79, 439 (2001) R.A.Henriksen and V.K.Hanks, Arterioscler. Thromb. Vasc. Biol., 22, 861 (2002) Ref: Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003); Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005).
Cas : 352017-71-1