Size : 25
P1(RMB) : 2090
MW : 646.75
One letter sequence : TFRGAP-NH2
Molecular Formula : C29H46N10O7
Description : This peptide is a human PAR-3-derived tethered ligand, which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR-expressing cells.
PAR3 Tethered Ligand (Human) / Activates PAR1 and PAR2
This peptide is the 1-6 fragment of the protease-activated receptor 3 (PAR-3), which induces ERK activation in human carcinoma cells endogeneously expressing PAR1 and PAR3. This effect is completely abolished by single alanine substitution at positions 3, 4 and 6 in the peptide. PAR-3 allosterically regulates PAR1 signaling by receptor dimerization governing increased endothelial permeability. Targeting of PAR3 may mitigate the effects of PAR1 in activating endothelial responses such as vascular inflammation. However this peptide does not affect VEGF release or expression.
Literature Reference : K.K.Hansen et al., Immunology, 112, 183 (2004)
Kaufmann, R. et al. Regul. Pept. 125, 61( 2005)
McLaughlin, J. et al. PNAS 104, 5662 (2007)
Arisato, T. et al. Cell. Mol. Life Sci. 60, 1420 (2003)