Size : 1
P1(RMB) : 278
MW : 1053.2
One letter sequence : VPQYGYLTL-OH
Molecular Formula : N/A
Description : This peptide is the CD8 T cell epitope from adeno-associated virus 2 (AAV2) capsid. Liver toxicity observed in a clinical trial of AAV2 delivered systemically to patients with hemophilia was ascribed to killing of vector-transduced hepatocytes by capsid-specific T-cells.
Literature Reference : Murphy, S. et al. Blood (ASH Annual Meeting Abstracts), 108 (2006)
Mingozzi, F. et al. Nature Medicine 10.1038/nm1549 (2007)
Wang, L. et al. Therapy. 18, 185 (2007).
Cas : N/A