Glp-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Lys-Cys-Arg-Cys-Tyr-Ser(Cys7 and Cys28/Cys13 and Cys33/Cys17 and Cys35 Bridge)
Size : 1
P1(RMB) : 5110
MW : 4295.95
One letter sequence : Glp-FTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS(Cys7 and Cys28/Cys13 and Cys33/Cys17 and Cys35 Bridge)
Molecular Formula : C176H277N57O55S7
Description : The peptide was found in the venom of the scorpionc Leiurus quinquestriatus, is a Ca2+-activated K+ channel blocker.
Literature Reference : G.Gimenez-Gallego et al., Proc. Natl. Acad. Sci. USA, 85, 3329 (1988)
R.MacKinnon and C.Miller, Science, 245, 1382 (1989)
N.A.Castle et al., Trends Neurosci., 12, 59 (1989)
T.R.Werkman et al., Neuroscience, 50, 935 (1992)
T.R.Jones et al., J. Appl. Physiol., 74, 1879 (1993)
C.Miller, Neuron, 15, 5 (1995)
K.G.Chandy et al., Trends Pharmacol. Sci., 25, 280 (2004)
Cas : 95751-30-7
