Size : 1
P1(RMB) : 398
MW : 1023.1
One letter sequence : SEVNLDAEF
Molecular Formula : C44H66N10O18
Description : Peptide substrate that corresponds to the mutant junctional sequence of the amyloid precursor protein (APP) found in a Swedish family with early-onset Alzheimer's disease, henceforth referred to as the "Swedish "mutation. The peptide has been used for assaying cleavage at leucine-aspartate by cathespin G and chymotrypsin, whereas neither cathepsin B, D, nor L generated any products.
Literature Reference : M. Citron et al., Nature, 360, 672 (1992); M. Mullan et al., Nature Gen., 1, 345 (1992); S.R. Sahasrabudhe et al., J. Biol. Chem., 268, 16699 (1993)