Chinese Peptide Company


DABCYL-TNF-a-EDANS (-4 to +6), human
Size : 0.5
P1(RMB) : 460
MW : 1573.8
One letter sequence : Dabcyl-LAQAVRSSSR-Edans
Molecular Formula : C70H104N22O18S1
Description : TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.
Literature Reference : A.J. H.Gearing et al., Nature , 370, 555 (1994)K.M. Mohler et al., Nature , 370, 218 (1994)Becker BF, et al.Biol Chem 383, 1821-6 (2002)Mohler KM, et al., Nature 370, 218-20. (1994)
Cas :