Chinese Peptide Company


MMP-2 Substrate, Fluorogenic
Size : 0.5
P1(RMB) : 398
MW : 1093.2 
One letter sequence : Mca-PLA-Nva-Dap(Dnp)-AR-NH2
Molecular Formula : C49H68N14O15
Description : Sensitive substrate for continuous assays and in situ determination of the matrix metalloproteinase activity. When cleaved at the Gly-Leu bond it separates the highly fluorescent Mca group from the efficient 2,4-dinitrophenyl quencher and results in the increase of fluorescence intensity. The kcat/km value for the punctuated metalloproteinase (MMP-7) and for gelatinase (MMP-2), e.g., are 1.7•105 and 6.3•105 M-1s-1, respectively.
Literature Reference : G. Murphy, et al., J. Biol. Chem. 269, 6632 (1994).
Cas :