Size : 1
P1(RMB) : 582
MW : 1145.2
One letter sequence : Mca-YVADAP-Lys(DNP)
Molecular Formula : C53H64N10O19
Description : Highly fluorescent substrate for the determination of caspase-1 (ICE) and caspase-1-like enzyme activities. Cleavage of this substrate at position P1 Asp causes continuous fluorescent assay monitored at emission wavelength of 393 nM. Furthermore, caspase-3 (apopain, CPP-32) is only weakly active on this substrate. Both caspase-1 and caspase-3 are involved in apoptosis.
Literature Reference : M. Enari et al., Nature, 380, 723 (1996)
Cas : [189696-01-3]